Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952079 | 0.93 | PDE5A (0.32) | — | |
| Trifluoroacetic Acid SCHEMBL9960928 | 0.91 | WHR1 (0.31) | PDE11AADORA2AADORA2B | |
| SCHEMBL9952126 | 0.86 | PDE5A (0.33) | — | |
| SCHEMBL9960535 | 0.86 | PDE5A (0.32) | PDE11AADORA2AADORA2B | |
| Trifluoroacetic Acid SCHEMBL9929170 | 0.85 | PIK3CD (0.41) | — | |
| Trifluoroacetic Acid SCHEMBL9953716 | 0.85 | PIK3CD (0.36) | PDE11AADORA2AADORA2B | |
| SCHEMBL9952915 | 0.84 | PDE5A (0.31) | PDE11A | |
| SCHEMBL9960517 | 0.84 | PDE5A (0.31) | — | |
| SCHEMBL9953804 | 0.83 | ALDH1A1 (0.31) | — | |
| SCHEMBL9952734 | 0.82 | HTT (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |