SCHEMBL9954024

SCHEMBL9954024

CNc1ccc(SC(F)(F)F)cn1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.41
HCAR3 P49019 1/20 0.41
NNMT P40261 1/20 0.40
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PTPRZ1 P23471 3/20 0.39
PTPN1 P18031 2/20 0.39
IGF1R P08069 1/20 0.39
HSD17B10 Q99714 1/20 0.37
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
KIT P10721 1/20 0.34
BRAF P15056 1/20 0.34
MAPK1 P28482 1/20 0.34
AKT1 P31749 1/20 0.34
KDR P35968 1/20 0.34
TDO2 P48775 1/20 0.34
PDE2A O00408 1/20 0.34
APP P05067 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23036866 0.81 KDM4E (0.44) SMN1; SMN2KDM4EALDH1A1TDP1PTPRZ1
SCHEMBL4248528 0.76 HCAR3 (0.46) HCAR3NNMTKDM4EALDH1A1NPC1
SCHEMBL10564144 0.75 KDM4E (0.43) SMN1; SMN2KDM4EALDH1A1TDP1PTPRZ1
SCHEMBL12147800 0.75 SMN1; SMN2 (0.45) SMN1; SMN2KDM4EALDH1A1TDP1PTPRZ1
SCHEMBL20196574 0.72 HCAR3 (0.42) SMN1; SMN2HCAR3NNMTNPC1RAB9A
SCHEMBL15847002 0.71 KDM4E (0.43) SMN1; SMN2KDM4EALDH1A1TDP1PTPRZ1
SCHEMBL9953818 0.71 KDM4E (0.43) SMN1; SMN2KDM4EALDH1A1TDP1PTPRZ1
SCHEMBL9838927 0.71 KDM4E (0.43) SMN1; SMN2KDM4EALDH1A1TDP1PTPRZ1
SCHEMBL16813070 0.71 KDM4E (0.63) SMN1; SMN2NNMTKDM4EALDH1A1TDP1
SCHEMBL14392740 0.71 KDM4E (0.43) SMN1; SMN2KDM4EALDH1A1TDP1PTPRZ1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006429-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2019-02-06 EP disclosed
EP-3006429-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2019-02-06 EP disclosed
EP-2881386-B1 AMIDE COMPOUND SUMITOMO CHEMICAL CO (JP) 2018-03-07 EP disclosed
EP-2655337-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2016-11-23 EP disclosed
EP-2655337-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2016-11-23 EP disclosed
US-9392791-B2 Amide compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-07-19 US disclosed
US-9392791-B2 Amide compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-07-19 US disclosed
CN-104395289-B Amide compound and Pesticidal purposes thereof SUMITOMO CHEMICAL CO.,LTD. (JP) 2016-05-11 CN disclosed
EP-3006429-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO., LTD. (JP) 2016-04-13 EP disclosed
EP-3006429-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO., LTD. (JP) 2016-04-13 EP disclosed
EP-2865672-A1 FUSED HETEROCYCLIC COMPOUND Sumitomo Chemical Co., Ltd (JP) 2015-04-29 EP disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed
EP-2655337-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF Sumitomo Chemical Company Limited (JP) 2013-10-30 EP disclosed
WO-2012086848-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-28 WO disclosed
WO-2012086848-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 SMN1; SMN2 2358/4885HCAR3 246/4885NNMT 1995/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 SMN1; SMN2 2445/4885HCAR3 255/4885NNMT 1923/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.