SCHEMBL9954096

SCHEMBL9954096

O=C(C1CCc2nc(Nc3cccc(Cl)c3)ncc2C1)N1CCCCC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.58
MAOB P27338 2/20 0.58
MAOA P21397 1/20 0.52
CNR2 P34972 4/20 0.44
CYP3A4 P08684 3/20 0.44
CYP2C9 P11712 3/20 0.44
CYP2C19 P33261 3/20 0.44
ALDH1A1 P00352 2/20 0.44
CDK5 Q00535 4/20 0.43
CDK5R1 Q15078 4/20 0.43
CCNA2 P20248 3/20 0.43
CDK2 P24941 3/20 0.43
CDK1 P06493 2/20 0.43
CCNB1 P14635 2/20 0.43
CYP1A2 P05177 2/20 0.43
KDR P35968 2/20 0.43
CYP2D6 P10635 1/20 0.43
MEN1 O00255 1/20 0.42
RECQL P46063 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9954113 0.86 GRM5 (0.61) GRM5MAOBMAOACNR2CYP3A4
SCHEMBL9956217 0.83 GRM5 (0.57) GRM5MAOBMAOACNR2CYP3A4
SCHEMBL9954811 0.82 GRM5 (0.59) GRM5MAOBMAOACNR2CYP3A4
SCHEMBL9955388 0.82 GRM5 (0.58) GRM5MAOBMAOAKDR
SCHEMBL9954136 0.80 GRM5 (0.54) GRM5MAOBMAOACNR2CYP3A4
SCHEMBL9955875 0.80 MAOB (0.61) GRM5MAOBMAOACDK5CDK5R1
SCHEMBL9959960 0.80 GRM5 (0.53) GRM5MAOBMAOACNR2CYP3A4
SCHEMBL9955054 0.78 MAOB (0.61) GRM5MAOBMAOACDK5CDK5R1
SCHEMBL9954102 0.76 MAOB (0.61) GRM5MAOBMAOAKDRHDAC3
SCHEMBL9960032 0.74 GRM5 (1.00) GRM5MAOBMAOACDK5CDK5R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012085167-A1 METABOTROPIC GLUTAMATE RECEPTOR MODULATORS MERZ PHARMA GMBH & CO. KGAA (DE) 2012-06-28 WO claimed
WO-2012085167-A1 METABOTROPIC GLUTAMATE RECEPTOR MODULATORS MERZ PHARMA GMBH & CO. KGAA (DE) 2012-06-28 WO disclosed