Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952127 | 0.88 | PIK3CD (0.53) | PIK3CDADORA2BADORA1MTORPIP4K2A | |
| SCHEMBL9952877 | 0.84 | PIK3CD (0.48) | PIK3CDADORA2BADORA1MTORDYRK1A | |
| SCHEMBL9929140 | 0.84 | PIK3CD (0.56) | PIK3CDMTORDYRK1APIK3CAPIK3CB | |
| SCHEMBL9952875 | 0.83 | PIK3CD (0.45) | PIK3CDADORA2BADORA1PIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL9929384 | 0.83 | PIK3CD (0.55) | PIK3CDMTORDYRK1APIK3CAPIK3CB | |
| SCHEMBL9954291 | 0.82 | PIK3CD (0.45) | PIK3CDADORA2BADORA1MTORPIK3CA | |
| SCHEMBL9928991 | 0.81 | PIK3CD (0.49) | PIK3CDDYRK1A | |
| SCHEMBL16945988 | 0.79 | PIK3CD (0.53) | PIK3CDMTORDYRK1A | |
| SCHEMBL9954296 | 0.79 | PIK3CD (0.48) | PIK3CD | |
| SCHEMBL9952129 | 0.79 | PIK3CD (0.46) | PIK3CDADORA2BADORA1MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |