Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16945988 | 0.89 | PIK3CD (0.53) | PIK3CD | |
| SCHEMBL9929140 | 0.86 | PIK3CD (0.56) | PIK3CD | |
| Hydrochloric Acid SCHEMBL9929384 | 0.85 | PIK3CD (0.55) | PIK3CD | |
| SCHEMBL9928991 | 0.82 | PIK3CD (0.49) | PIK3CDNR1H2NR1H3 | |
| SCHEMBL17341787 | 0.82 | PIK3CD (0.58) | PIK3CDTRPA1 | |
| SCHEMBL9952127 | 0.81 | PIK3CD (0.53) | PIK3CD | |
| SCHEMBL9952877 | 0.79 | PIK3CD (0.48) | PIK3CDNR1H2NR1H3 | |
| SCHEMBL9954293 | 0.79 | PIK3CD (0.48) | PIK3CD | |
| SCHEMBL9929484 | 0.79 | PIK3CD (0.50) | PIK3CD | |
| SCHEMBL14736069 | 0.79 | PIK3CD (0.51) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |