Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260913 | 0.88 | ALDH1A1 (0.58) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL575530 | 0.82 | ALDH1A1 (0.65) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL331716 | 0.76 | — | — | |
| SCHEMBL1963931 | 0.74 | — | — | |
| Ammonia Solution, Strong SCHEMBL28774943 | 0.72 | ALDH1A1 (0.52) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL12050694 | 0.71 | ALDH1A1 (0.58) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL14460704 | 0.71 | ALDH1A1 (0.58) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL4596643 | 0.71 | ALDH1A1 (0.58) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL4102536 | 0.71 | ALDH1A1 (0.58) | ALDH1A1USP2TSHRCA1CA2 | |
| SCHEMBL28896513 | 0.70 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655375-B1 | PYRIMIDINONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF | SANOFI SA (FR) | 2014-12-03 | — | — | EP | disclosed |
| EP-2655375-A1 | PYRIMIDINONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF | SANOFI (FR) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085244-A1 | PYRIMIDINONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF | SANOFI (FR) | 2012-06-28 | — | — | WO | disclosed |