Sugi Predict

Sugi Predict / Compounds / SCHEMBL9956573

SCHEMBL9956573

SCHEMBL9956573

Cc1ccc(-c2cn3nc(-c4cccc(S(=O)(=O)N(C)C)c4)ccc3n2)cc1NC(=O)C(C)(C)C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 9/20 0.50
▸ HPGD P15428 2/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ HSD17B10 Q99714 2/20 0.50
▸ GFER P55789 2/20 0.50
▸ RAB9A P51151 2/20 0.50
▸ NPC1 O15118 1/20 0.50
▸ TP53 P04637 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ KDM4E B2RXH2 6/20 0.46
▸ PIK3CD O00329 3/20 0.42
▸ PIK3CG P48736 3/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.41
▸ NPSR1 Q6W5P4 2/20 0.41
▸ GLA P06280 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ MAPK1 P28482 1/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.40
▸ LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9955311 0.86 CSNK1D (0.41) ALDH1A1HPGDKDM4ELMNACSNK1D
SCHEMBL9956458 0.85 CSNK1D (0.42) LMNACSNK1DCSNK1EMAPT
SCHEMBL9956786 0.85 CSNK1D (0.42) ALDH1A1KDM4EPIK3CGGLAGAA
SCHEMBL9957320 0.84 AURKA (0.47) TP53PIK3CGCSNK1DCSNK1EMAPT
SCHEMBL9957106 0.83 BLM (0.42) TP53PIK3CDPIK3CGCSNK1DCSNK1E
SCHEMBL9957330 0.82 MAPT (0.43) ALDH1A1RAB9ANPC1TP53KDM4E
SCHEMBL9955529 0.82 PIK3CG (0.43) ALDH1A1KDM4EPIK3CGGLAGAA
SCHEMBL9956973 0.82 FYN (0.44) ALDH1A1HPGDHSD17B10KDM4ERXFP1
SCHEMBL9957095 0.82 PIK3CG (0.52) ALDH1A1KDM4EPIK3CGGLAGAA
SCHEMBL9957565 0.82 CSNK1D (0.44) TP53PIK3CDPIK3CGRXFP1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2635578-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES Hengrui (USA) Ltd. (US) 2013-09-11 — — EP claimed
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI (USA), LTD. 2012-07-12 — — US claimed
WO-2012088411-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PAMLICO PHARMACEUTICAL INC. (US) 2012-06-28 — — WO claimed
EP-2635578-B1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES HENGRUI USA LTD (US) 2015-12-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120178751-A1 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES PRXL2A, CDK2, CCNA2 ALDH1A1 334/4885HPGD 1136/4885MEN1 1837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.