Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | CALCA | P06881 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493062 | 0.85 | EGLN1 (0.56) | EGLN1HIF1A | |
| SCHEMBL2497399 | 0.80 | EGLN1 (0.42) | EGLN1HIF1AALDH1A1POLBESR2 | |
| SCHEMBL2496160 | 0.77 | EGLN1 (0.43) | EGLN1HIF1AALDH1A1POLBESR2 | |
| SCHEMBL2501559 | 0.77 | EGLN1 (0.47) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL2578845 | 0.75 | EGLN1 (0.51) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL12101596 | 0.75 | EGLN1 (0.46) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL337574 | 0.74 | EGLN1 (0.49) | EGLN1HIF1AMEN1NPC1KMT2A | |
| SCHEMBL2576963 | 0.74 | HIF1A (0.48) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL337374 | 0.74 | EGLN1 (0.49) | EGLN1HIF1AMEN1NPC1RAB9A | |
| SCHEMBL12101565 | 0.74 | EGLN1 (0.43) | EGLN1HIF1AALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150251-B9 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2150251-B1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2012-06-27 | — | — | EP | disclosed |