Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660904 | 0.87 | ADORA2A (0.54) | ADORA2ANPC1RAB9APOLBLMNA | |
| SCHEMBL2660974 | 0.84 | GCK (0.59) | ADORA2ANPC1RAB9APOLBLMNA | |
| SCHEMBL9958116 | 0.81 | NPC1 (0.52) | ADORA2ANPC1RAB9ALMNAMAPT | |
| SCHEMBL2661038 | 0.79 | ADORA2A (0.56) | ADORA2ANPC1RAB9APOLBLMNA | |
| SCHEMBL2660257 | 0.77 | GCK (0.53) | ADORA2ANPC1RAB9APOLBMAPT | |
| SCHEMBL2660820 | 0.77 | NPC1 (0.53) | ADORA2ANPC1RAB9ALMNAMAPT | |
| SCHEMBL2660279 | 0.74 | SMN1; SMN2 (0.52) | ADORA2ANPC1RAB9ALMNAMAPT | |
| SCHEMBL9958316 | 0.74 | GCK (0.71) | ADORA2APOLBGCKKMT2A | |
| Ammonia Solution, Strong SCHEMBL19469522 | 0.69 | PPARA (0.49) | POLBLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL2660231 | 0.69 | ADORA2A (0.47) | ADORA2ANPC1RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | claimed |