Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.71 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656113 | 0.86 | GCK (0.74) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL9958195 | 0.84 | GCK (0.62) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2656632 | 0.83 | GCK (1.00) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2655826 | 0.82 | GCK (0.82) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2655845 | 0.78 | GCK (0.63) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2656364 | 0.78 | GCK (0.80) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2657524 | 0.78 | GCK (0.80) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2657915 | 0.78 | GCK (0.63) | GCKADORA2APOLBKMT2A | |
| SCHEMBL2654866 | 0.78 | GCK (0.65) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2657284 | 0.77 | GCK (0.89) | GCKADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | claimed |