Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 2/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655845 | 0.86 | GCK (0.63) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL9958316 | 0.84 | GCK (0.71) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL9958151 | 0.83 | GCK (0.45) | GCKADORA2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL2657915 | 0.80 | GCK (0.63) | GCKADORA2AKMT2ARAB9ANPC1 | |
| SCHEMBL2656113 | 0.79 | GCK (0.74) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2656945 | 0.77 | GCK (0.67) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2656632 | 0.77 | GCK (1.00) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2656431 | 0.77 | GCK (0.59) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2655826 | 0.75 | GCK (0.82) | GCKADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL2654866 | 0.75 | GCK (0.65) | GCKADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | claimed |