Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 7/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958035 | 0.94 | FLT3 (0.40) | FLT3KITBRAFKDRNEK7 | |
| SCHEMBL18424542 | 0.87 | KIT (0.44) | FLT3KITBRAFKDRNEK7 | |
| SCHEMBL25793273 | 0.81 | KIT (0.41) | FLT3KITBRAFKDRNEK7 | |
| SCHEMBL1012949 | 0.81 | BRAF (0.47) | FLT3KITBRAFKDR | |
| SCHEMBL27217912 | 0.78 | SMN1; SMN2 (0.44) | KDRTSHRMEN1KMT2A | |
| SCHEMBL23966921 | 0.76 | FAAH (0.47) | FLT3KITBRAFKDR | |
| SCHEMBL2533492 | 0.75 | NEK7 (0.35) | FLT3KITBRAFKDRNEK7 | |
| SCHEMBL27217824 | 0.75 | SMN1; SMN2 (0.42) | TSHRMEN1KMT2A | |
| SCHEMBL24133584 | 0.74 | HCAR2 (0.32) | FLT3KITBRAFKDR | |
| SCHEMBL1255991 | 0.74 | NEK7 (0.49) | FLT3KITBRAFKDRNEK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467137-A1 | BIARYL COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2012-06-27 | — | — | EP | disclosed |