Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27322551 | 0.79 | CYP2D6 (0.38) | CYP1A2CYP2D6CYP2C19CYP2C9SCN3A | |
| SCHEMBL26027674 | 0.79 | CYP1A2 (0.38) | CYP1A2CYP2D6CYP2C19CYP2C9LMNA | |
| SCHEMBL30694817 | 0.79 | KDM4E (0.50) | CYP1A2CYP2D6CYP2C19CYP3A4KDM4E | |
| SCHEMBL25369019 | 0.79 | KDM4E (0.50) | CYP1A2CYP2D6CYP2C19CYP3A4KDM4E | |
| SCHEMBL27371895 | 0.78 | RORC (0.46) | SCN3A | |
| SCHEMBL27376455 | 0.78 | KDM4E (0.49) | CYP1A2CYP2D6CYP2C19CYP3A4KDM4E | |
| SCHEMBL32684924 | 0.77 | CYP1A2 (0.38) | CYP1A2CYP2D6CYP2C19CYP2C9KMT2A | |
| SCHEMBL22504164 | 0.76 | S1PR2 (0.39) | CYP1A2CYP2D6CYP2C19CYP2C9KDM4E | |
| SCHEMBL22489532 | 0.76 | MRGPRX4 (0.51) | SCN3AHTR2A | |
| SCHEMBL16220025 | 0.76 | SCN3A (0.42) | SCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |
| CN-101379036-B | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE | 2011-06-01 | — | — | CN | disclosed |
| CN-101379036-A | Anthranilamide/2-amino-heteroarene carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |