Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1830650 | 0.82 | ATM (0.52) | BACE1APP | |
| SCHEMBL10607243 | 0.77 | KDM4E (0.44) | BACE1 | |
| SCHEMBL10366330 | 0.77 | KDM4E (0.44) | BACE1 | |
| SCHEMBL31515327 | 0.77 | HDAC3 (0.43) | — | |
| SCHEMBL31515271 | 0.75 | HRH3 (0.45) | — | |
| SCHEMBL863663 | 0.75 | HTR2C (0.46) | — | |
| SCHEMBL14845662 | 0.74 | BACE1 (0.57) | BACE1APP | |
| SCHEMBL863293 | 0.74 | HRH3 (0.43) | — | |
| SCHEMBL19567109 | 0.74 | BACE1 (0.48) | BACE1APP | |
| Hydrochloric Acid SCHEMBL10502567 | 0.74 | HTR2C (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3176172-A1 | SPIROIMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS | Astrazeneca AB (SE) | 2017-06-07 | — | — | EP | disclosed |
| EP-2655378-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | AstraZeneca AB (SE) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087237-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |