Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9929511 | 0.69 | JAK2 (0.50) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL9929348 | 0.66 | JAK2 (0.45) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL9929113 | 0.66 | JAK2 (0.49) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL25245334 | 0.66 | JAK2 (0.49) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL22128054 | 0.65 | JAK2 (0.48) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL38651468 | 0.65 | JAK2 (0.43) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL26074490 | 0.65 | CD274 (0.50) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL31423952 | 0.64 | JAK2 (0.46) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL31423928 | 0.64 | JAK2 (0.48) | JAK2JAK1TYK2JAK3MAP3K5 | |
| SCHEMBL31423874 | 0.64 | JAK2 (0.50) | JAK2JAK1TYK2JAK3MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |