Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 3/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | FLT1 | P17948 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194956 | 0.89 | FGFR1 (0.44) | DRD2DRD4DRD3GRM4MIF | |
| SCHEMBL27945224 | 0.86 | GRM1 (0.39) | DRD2DRD4DRD3GRM4P2RY14 | |
| SCHEMBL9952579 | 0.84 | FLT3 (0.47) | DRD2DRD4DRD3GRM4P2RY14 | |
| SCHEMBL10195395 | 0.84 | P2RY14 (0.46) | GRM4P2RY14ADRA2AADRA2BADRA2C | |
| SCHEMBL9951834 | 0.84 | GRM1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL9959222 | 0.83 | P2RY14 (0.46) | GRM4P2RY14ADRA2AADRA2BADRA2C | |
| SCHEMBL10195390 | 0.83 | DRD2 (0.45) | DRD2DRD4DRD3GRM4P2RY14 | |
| SCHEMBL10194801 | 0.81 | GRM4 (0.39) | GRM4MIFP2RY14ADRA2AADRA2B | |
| SCHEMBL10194878 | 0.81 | P2RY14 (0.44) | GRM4P2RY14ADRA2AADRA2BADRA2C | |
| SCHEMBL10196871 | 0.81 | GRM4 (0.39) | GRM4MIFP2RY14ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | Merck Serono S.A. (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012084704-A1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |