Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1AN | Q9NWT6 | 9/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996364 | 1.00 | HIF1AN (0.51) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E | |
| SCHEMBL997895 | 0.96 | HIF1AN (0.48) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E | |
| SCHEMBL997896 | 0.96 | HIF1AN (0.48) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E | |
| SCHEMBL998195 | 0.87 | HIF1AN (0.54) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E | |
| SCHEMBL998194 | 0.87 | HIF1AN (0.54) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E | |
| SCHEMBL997271 | 0.84 | TUBB1 (0.48) | SMN1; SMN2KDM4EALDH1A1TUBB1LMNA | |
| SCHEMBL997270 | 0.84 | TUBB1 (0.48) | SMN1; SMN2KDM4EALDH1A1TUBB1LMNA | |
| SCHEMBL997056 | 0.84 | TUBB1 (0.58) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E | |
| SCHEMBL997051 | 0.84 | TUBB1 (0.58) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E | |
| SCHEMBL998657 | 0.83 | HIF1AN (0.51) | HIF1ANKEAP1NFE2L2SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |