Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1AN | Q9NWT6 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998195 | 1.00 | HIF1AN (0.54) | HIF1ANSMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL996376 | 0.93 | HIF1AN (0.53) | HIF1ANMAPTALDH1A1ABCG2TUBB1 | |
| SCHEMBL996379 | 0.93 | HIF1AN (0.53) | HIF1ANMAPTALDH1A1ABCG2TUBB1 | |
| SCHEMBL998223 | 0.92 | HIF1AN (0.54) | HIF1ANMAPTALDH1A1ABCG2TUBB1 | |
| SCHEMBL998221 | 0.92 | HIF1AN (0.54) | HIF1ANMAPTALDH1A1ABCG2TUBB1 | |
| SCHEMBL998259 | 0.89 | KEAP1 (0.59) | HIF1ANSMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL998257 | 0.89 | KEAP1 (0.59) | HIF1ANSMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL997051 | 0.88 | TUBB1 (0.58) | HIF1ANSMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL997056 | 0.88 | TUBB1 (0.58) | HIF1ANSMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL998657 | 0.87 | HIF1AN (0.51) | HIF1ANSMN1; SMN2KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |