Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960029 | 0.86 | FAAH (0.62) | FAAHPLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL2159739 | 0.86 | FAAH (0.79) | FAAHPLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL9958778 | 0.85 | FAAH (0.67) | FAAHPLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL2197934 | 0.85 | FAAH (0.81) | FAAHPLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL9959139 | 0.85 | FAAH (0.65) | FAAHPLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL10234769 | 0.84 | FAAH (0.74) | FAAHPLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL2159717 | 0.84 | FAAH (0.74) | FAAHPLA2G2AALDH1A1MAPTMAPK1 | |
| SCHEMBL2159916 | 0.83 | FAAH (0.87) | FAAHPLA2G2AALDH1A1MAPTMAPK1 | |
| SCHEMBL9959494 | 0.83 | FAAH (0.68) | FAAHPLA2G2AKDM4EALDH1A1MAPT | |
| SCHEMBL9951898 | 0.83 | FAAH (0.65) | FAAHPLA2G2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088431-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012088431-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2012-06-28 | — | — | WO | disclosed |