Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5523941 | 0.80 | MAPK8 (0.57) | PARP10MAPTNPC1RAB9AMAPK8 | |
| SCHEMBL30693359 | 0.80 | MAPK8 (0.57) | PARP10MAPTNPC1RAB9AMAPK8 | |
| SCHEMBL9959802 | 0.80 | PARP10 (0.45) | PARP10MAPTNPC1RAB9AMAPK8 | |
| SCHEMBL2116015 | 0.79 | MKNK1 (0.45) | MAPTNPC1RAB9AMAPK1SMN1; SMN2 | |
| SCHEMBL792643 | 0.78 | PARP10 (0.46) | PARP10MAPTNPC1RAB9AMRGPRX1 | |
| SCHEMBL27569231 | 0.75 | PARP10 (0.51) | PARP10MAPTNPC1RAB9AMAPK8 | |
| SCHEMBL7512439 | 0.75 | PARP10 (0.48) | PARP10MAPTNPC1RAB9AMAPK8 | |
| SCHEMBL27890736 | 0.73 | MKNK1 (0.46) | NPC1RAB9ASMN1; SMN2IKBKBMAP2K1 | |
| SCHEMBL792641 | 0.72 | PARP10 (0.45) | PARP10MAPTNPC1RAB9AGCK | |
| SCHEMBL14062131 | 0.71 | CDC7 (0.46) | IKBKBMAP2K1CLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655330-A1 | SUBSTITUTED PYRIDINES AS SODIUM CHANNEL BLOCKERS | Purdue Pharma LP (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085650-A1 | SUBSTITUTED PYRIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2012-06-28 | — | — | WO | disclosed |