Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959798 | 0.80 | PARP10 (0.45) | PARP10CTNNB1KDM5AKDM4CKDM5B | |
| SCHEMBL792641 | 0.77 | PARP10 (0.45) | PARP10CXCL8GCKMAPTNPC1 | |
| SCHEMBL2116017 | 0.76 | MKNK1 (0.45) | MAPTNPC1CDC7MAP2K1CLK4 | |
| SCHEMBL30096560 | 0.75 | IKBKB (0.46) | CDC7MAP2K1CLK4DYRK1BJAK2 | |
| SCHEMBL792643 | 0.73 | PARP10 (0.46) | PARP10CTNNB1KDM5AKDM4CKDM5B | |
| SCHEMBL14746537 | 0.72 | PARP10 (0.45) | PARP10CXCL8MAPTNPC1CDC7 | |
| SCHEMBL30693359 | 0.71 | MAPK8 (0.57) | PARP10MAPTNPC1HTTMAPK8 | |
| SCHEMBL5523941 | 0.71 | MAPK8 (0.57) | PARP10MAPTNPC1HTTMAPK8 | |
| SCHEMBL1758364 | 0.71 | IKBKB (0.47) | CDC7MAP2K1CLK4DYRK1BJAK2 | |
| SCHEMBL7201932 | 0.71 | BCAT2 (0.46) | CDC7MAP2K1CLK4DYRK1BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655330-A1 | SUBSTITUTED PYRIDINES AS SODIUM CHANNEL BLOCKERS | Purdue Pharma LP (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012085650-A1 | SUBSTITUTED PYRIDINES AS SODIUM CHANNEL BLOCKERS | PURDUE PHARMA L.P. (US) | 2012-06-28 | — | — | WO | disclosed |