Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CTSV | O60911 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 4/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.47 |
| ▸ | MAX | P61244 | 1/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116860 | 0.85 | POLB (0.56) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL11232948 | 0.82 | ABCB1 (0.57) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL25146420 | 0.81 | MAPK1 (0.53) | MAPTGLRA1HTR1AADRA1DADRA1A | |
| SCHEMBL1494020 | 0.80 | POLB (0.48) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL18863826 | 0.79 | POLB (0.54) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL29894219 | 0.79 | POLB (0.54) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL13504298 | 0.79 | CTSV (0.54) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL10585706 | 0.78 | MEN1 (0.56) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL31756984 | 0.78 | MEN1 (0.56) | POLBMEN1KMT2AMAPTCTSV | |
| SCHEMBL8316270 | 0.78 | MEN1 (0.55) | POLBMEN1KMT2AMAPTCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479528-B2 | Heat shock protein 90 inhibitors | TAIPEI MEDICAL UNIVERSITY (TW) | 2022-10-25 | — | — | US | disclosed |
| US-20200039923-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2020-02-06 | — | — | US | disclosed |
| US-20200039923-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | TAIPEI MEDICAL UNIVERSITY (TW) | 2020-02-06 | — | — | US | disclosed |
| US-9302998-B2 | Aryl triazole compounds with antitumoural activity | SIGMA-TAU RESEARCH SWITZERLAND S.A. (CH) | 2016-04-05 | — | — | US | disclosed |
| EP-2655345-B1 | ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY | SIGMA TAU RES SWITZERLAND SA (CH) | 2015-02-18 | — | — | EP | disclosed |
| US-20140329812-A1 | ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY | SIGMA-TAU RESEARCH SWITZERLAND S.A. (CH) | 2014-11-06 | — | — | US | disclosed |
| EP-2655345-A1 | ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY | SIGMA-TAU Research Switzerland S.A. (CH) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012084602-A1 | ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY | SIGMA-TAU RESEARCH SWITZERLAND S.A. (CH) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329812-A1 | ARYL TRIAZOLE COMPOUNDS WITH ANTITUMOURAL ACTIVITY | HSP90AB1, HSP90AB2P, HSP90AA1 | POLB 2891/4885MEN1 4705/4885KMT2A 4102/4885 |
| US-20200039923-A1 | HEAT SHOCK PROTEIN 90 INHIBITORS | HSP90AB1, HSP90AB2P, HSP90AA1 | POLB 2443/4885MEN1 4724/4885KMT2A 4247/4885 |
| US-11479528-B2 | Heat shock protein 90 inhibitors | HSP90AB1, HSP90AB2P, HSP90AA1 | POLB 2443/4885MEN1 4724/4885KMT2A 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.