Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656470 | 0.91 | SCN3A (0.44) | GCKKCNH2 | |
| SCHEMBL9960421 | 0.89 | GCK (0.43) | GCKKCNH2MEN1PKMHTT | |
| SCHEMBL2657686 | 0.78 | GCK (0.47) | GCKMEN1KMT2A | |
| SCHEMBL2655672 | 0.74 | BRD4 (0.49) | GCKMEN1HTTKMT2A | |
| SCHEMBL2661717 | 0.73 | NR3C1 (0.51) | GCK | |
| SCHEMBL27925069 | 0.67 | MEN1 (0.49) | MEN1PKMHTTKMT2AHIF1A | |
| SCHEMBL6563302 | 0.67 | GCK (0.55) | GCKKCNH2MEN1HTTKMT2A | |
| SCHEMBL2656464 | 0.66 | POLB (0.52) | MEN1KMT2A | |
| SCHEMBL28749892 | 0.66 | GCK (0.46) | GCKMEN1KMT2A | |
| SCHEMBL17591077 | 0.65 | MEN1 (0.71) | MEN1PKMHTTKMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125735-B1 | 2,2,2-TRI-SUBSTITUTED ACETAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION | ADVINUS THERAPEUTICS PRIVATE LTD (IN) | 2012-06-27 | — | — | EP | claimed |