⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960703 | 0.87 | HTT (0.30) | — | |
| SCHEMBL9960779 | 0.84 | — | — | |
| SCHEMBL9960630 | 0.73 | — | — | |
| SCHEMBL9960582 | 0.71 | — | — | |
| SCHEMBL9960781 | 0.71 | — | — | |
| SCHEMBL9960758 | 0.71 | — | — | |
| SCHEMBL9960716 | 0.70 | — | — | |
| SCHEMBL9960640 | 0.70 | PTGS2 (0.33) | — | |
| SCHEMBL9960993 | 0.68 | MYC (0.30) | — | |
| SCHEMBL9960708 | 0.68 | KDM4E (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10717715-B2 | Solid forms of ingenol 3-(3,5-diethylisoxazole-4-carboxylate) and method for preparing the same | INDENA S.P.A. (IT) | 2020-07-21 | — | — | US | claimed |
| EP-3510021-A1 | SOLID FORMS OF INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) AND METHOD FOR PREPARING THE SAME | Indena S.p.A. (IT) | 2019-07-17 | — | — | EP | claimed |
| US-20190210980-A1 | SOLID FORMS OF INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) AND METHOD FOR PREPARING THE SAME | INDENA S.P.A. (IT) | 2019-07-11 | — | — | US | claimed |
| WO-2018046337-A1 | SOLID FORMS OF INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) AND METHOD FOR PREPARING THE SAME | INDENA S.P.A. (IT) | 2018-03-15 | — | — | WO | claimed |
| EP-2655323-B1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LTD (IE) | 2017-12-20 | — | — | EP | claimed |
| EP-3223812-A1 | A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE FULL FACE OR 250 CM2 ON THE CHEST WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) | Leo Laboratories Limited (IE) | 2017-10-04 | — | — | EP | claimed |
| EP-3223813-A1 | A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE SCALP WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) | Leo Laboratories Limited (IE) | 2017-10-04 | — | — | EP | claimed |
| EP-3223814-A1 | A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE TRUNK (EXCEPT CHEST) AND EXTREMITIES WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) | Leo Laboratories Limited (IE) | 2017-10-04 | — | — | EP | claimed |
| US-20170258756-A1 | A Method for Topically Treating Actinic Keratosis on the Scalp with Ingenol 3-(3,5-diethylisoxazole-4-carboxylate) | LEO LABORATORIES LTD (IE) | 2017-09-14 | — | — | US | claimed |
| US-20170258769-A1 | A Method for Topically Treating Actinic Keratosis on the Trunk (except chest) and Extremities with Ingenol 3-(3,5-diethylisoxazole-4-carboxylate) | LEO LABORATORIES LTD (IE) | 2017-09-14 | — | — | US | claimed |
| US-9102687-B2 | Ingenol-3-acylates III and ingenol-3-carbamates | LEO LABORATORIES LIMITED (IE) | 2015-08-11 | — | — | US | claimed |
| WO-2015059577-A1 | A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE FULL BALDING SCALP WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) | LEO LABORATORIES LIMITED (IE) | 2015-04-30 | — | — | WO | claimed |
| WO-2015059572-A1 | A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) | LEO LABORATORIES LIMITED (IE) | 2015-04-30 | — | — | WO | claimed |
| WO-2015059574-A1 | A METHOD FOR TOPICALLY TREATING ACTINIC KERATOSIS ON THE TRUNK (EXCEPT CHEST) OR EXTREMITIES WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) | LEO LABORATORIES LIMITED (IE) | 2015-04-30 | — | — | WO | claimed |
| US-20150119434-A1 | Method for Topically Treating Actinic Keratosis with ingenol 3-(3,5-diethylisoxazole-4-carboxylate) | LEO LABORATORIES LIMITED (IE) | 2015-04-30 | — | — | US | claimed |
| US-20150119433-A1 | METHOD OF TREATING ACTINIC KERATOSIS ON THE FULL BALDING SCALP WITH INGENOL 3-(3,5-DIETHYLISOXAZOLE-4-CARBOXYLATE) | LEO LABORATORIES LIMITED (IE) | 2015-04-30 | — | — | US | claimed |
| US-20140303150-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2014-10-09 | — | — | US | claimed |
| WO-2014083198-A1 | DISPENSING DEVICE | LEO PHARMA A/S (DK) | 2014-06-05 | — | — | WO | claimed |
| EP-2655323-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO LABORATORIES LIMITED (IE) | 2013-10-30 | — | — | EP | claimed |
| WO-2012083953-A1 | INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES | LEO PHARMA A/S (DK) | 2012-06-28 | — | — | WO | claimed |