Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | LDHB | P07195 | 1/20 | 0.34 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9221 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TSHRGAAKDM4ETDP1 | |
| Furan SCHEMBL17140223 | 0.89 | ALDH1A1 (0.39) | ALDH1A1TSHRGAAKDM4ETDP1 | |
| SCHEMBL9946109 | 0.77 | GAA (0.47) | ALDH1A1TSHRGAAKDM4ETDP1 | |
| SCHEMBL31236254 | 0.76 | KDM4E (0.36) | ALDH1A1TSHRGAAKDM4ETDP1 | |
| SCHEMBL51391 | 0.74 | — | — | |
| SCHEMBL18187371 | 0.74 | KDM4E (0.42) | TSHRKDM4ETDP1 | |
| SCHEMBL28571795 | 0.72 | ALDH1A1 (0.54) | ALDH1A1TSHRGAAKDM4ETDP1 | |
| SCHEMBL28562313 | 0.72 | ALDH1A1 (0.54) | ALDH1A1TSHRGAAKDM4ETDP1 | |
| SCHEMBL28565958 | 0.72 | ALDH1A1 (0.54) | ALDH1A1TSHRGAAKDM4ETDP1 | |
| SCHEMBL28576319 | 0.72 | ALDH1A1 (0.54) | ALDH1A1TSHRGAAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468745-B1 | Process for the preparation of lapatinib and the salts thereof | ITALIANA SINT SPA (IT) | 2013-04-24 | — | — | EP | disclosed |
| EP-2468745-A1 | Process for the preparation of lapatinib and the salts thereof | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2012-06-27 | — | — | EP | disclosed |