Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9952078 | 0.81 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CGSMN1; SMN2 | |
| SCHEMBL9952266 | 0.77 | PIK3CD (0.46) | PIK3CDHTTMAPTTSHRSMN1; SMN2 | |
| SCHEMBL2717588 | 0.73 | PIK3CG (0.35) | PIK3CDHTTMAPK1TAAR1AURKA | |
| SCHEMBL2717118 | 0.73 | PIK3CD (0.48) | PIK3CDHTTPIK3CAPIK3CBPIK3CG | |
| SCHEMBL9952881 | 0.71 | PIK3CD (0.42) | PIK3CDHTTAURKAMAPTPIK3CG | |
| SCHEMBL9952453 | 0.69 | PIK3CD (0.42) | PIK3CDHTTMAPK1MAPTTSHR | |
| SCHEMBL9952996 | 0.68 | STK4 (0.38) | PIK3CDHTTMAPK1MAPTTSHR | |
| SCHEMBL9953808 | 0.68 | PIK3CD (0.38) | PIK3CDHTTMAPK1MAPTTSHR | |
| SCHEMBL9952100 | 0.68 | PIK3CD (0.42) | PIK3CDHTTMAPK1CHEK1CDK1 | |
| SCHEMBL9953050 | 0.68 | PIK3CD (0.39) | PIK3CDHTTMAPK1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Corporation (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2012087881-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | disclosed |