Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 18/20 | 0.43 |
| ▸ | KDR | P35968 | 11/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950506 | 0.82 | FGFR3 (0.65) | FGFR3KDR | |
| SCHEMBL9960972 | 0.81 | KDR (0.44) | FGFR3KDRFGFR1 | |
| SCHEMBL9960280 | 0.80 | FGFR3 (0.51) | FGFR3KDRFGFR1 | |
| SCHEMBL9960297 | 0.70 | FGFR3 (0.37) | FGFR3KDRFGFR1 | |
| SCHEMBL9949431 | 0.66 | FGFR3 (0.62) | FGFR3KDR | |
| SCHEMBL9949821 | 0.66 | FGFR3 (0.70) | FGFR3KDR | |
| SCHEMBL10177430 | 0.66 | MAP3K7 (0.46) | FGFR3KDRFGFR1 | |
| SCHEMBL9950054 | 0.65 | KDR (0.70) | FGFR3KDR | |
| SCHEMBL9949658 | 0.65 | KDR (0.67) | FGFR3KDR | |
| SCHEMBL10176117 | 0.65 | MAP3K7 (0.46) | FGFR3KDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088266-A2 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |