Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 14/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9960280 | 0.88 | FGFR3 (0.51) | KDRFGFR3FGFR1 | |
| SCHEMBL10176578 | 0.83 | MAP3K7 (0.46) | KDRFGFR3FGFR1MAP3K7TAB1 | |
| SCHEMBL9960965 | 0.81 | FGFR3 (0.43) | KDRFGFR3FGFR1 | |
| SCHEMBL9950431 | 0.80 | KDR (0.68) | KDRFGFR3 | |
| SCHEMBL10177301 | 0.76 | MAP3K7 (0.46) | KDRFGFR3FGFR1MAP3K7TAB1 | |
| SCHEMBL10176117 | 0.75 | MAP3K7 (0.46) | KDRFGFR3FGFR1MAP3K7TAB1 | |
| SCHEMBL9950410 | 0.74 | KDR (0.68) | KDRFGFR3 | |
| SCHEMBL9960297 | 0.73 | FGFR3 (0.37) | KDRFGFR3NR1H4FGFR1 | |
| SCHEMBL10177430 | 0.72 | MAP3K7 (0.46) | KDRFGFR3FGFR1MAP3K7TAB1 | |
| SCHEMBL9950520 | 0.72 | KDR (0.64) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012088266-A2 | SUBSTITUTED IMIDAZOPYRIDAZINES AND BENZIMIDAZOLES AS INHIBITORS OF FGFR3 | INCYTE CORPORATION (US) | 2012-06-28 | — | — | WO | claimed |