Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | F10 | P00742 | 9/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13429835 | 1.00 | KCNH2 (0.52) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL12064730 | 0.88 | KCNH2 (0.68) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL13429812 | 0.87 | KCNH2 (0.38) | KCNH2F10KDM4EALDH1A1POLB | |
| SCHEMBL9930022 | 0.87 | KCNH2 (0.52) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL14069788 | 0.87 | KCNH2 (0.52) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL9930200 | 0.86 | KCNH2 (0.53) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL14069901 | 0.86 | KCNH2 (0.53) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL13429763 | 0.84 | KCNH2 (0.51) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL9930387 | 0.84 | KCNH2 (0.51) | KCNH2F10MAOBMAOACYP2C19 | |
| SCHEMBL9964773 | 0.84 | KCNH2 (0.51) | KCNH2F10MAOBMAOACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157434-A1 | Antimicrobial heterocyclic compounds for treatment of bacterial infections | CSO of MicuRx Pharmaceuticals, Inc. | 2012-06-21 | — | — | US | disclosed |
| US-20120157434-A1 | Antimicrobial heterocyclic compounds for treatment of bacterial infections | CSO of MicuRx Pharmaceuticals, Inc. | 2012-06-21 | — | — | US | disclosed |
| WO-2008108988-A1 | ANTIMICROBIAL HETEROCYCLIC COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS | MICURX PHARMACEUTICALS, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157434-A1 | Antimicrobial heterocyclic compounds for treatment of bacterial infections | NISCH, NOD1, NQO1 | KCNH2 1295/4885F10 2649/4885MAOB 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.