SCHEMBL9965353

SCHEMBL9965353

c1ccc2c(c1)ccc1c2ccc2c3ccccc3sc21

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPRT1 P00492 3/20 0.58
GPR3 P46089 1/20 0.52
ALDH1A1 P00352 3/20 0.50
HSD17B10 Q99714 2/20 0.50
CYP2A6 P11509 2/20 0.50
TSHR P16473 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
PAX8 Q06710 1/20 0.43
MAPT P10636 4/20 0.43
CYP1B1 Q16678 2/20 0.43
HIF1A Q16665 1/20 0.43
RAB9A P51151 2/20 0.42
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CYP1A1 P04798 1/20 0.41
ALOX5 P09917 1/20 0.40
LMNA P02545 1/20 0.40
CYP3A4 P08684 1/20 0.40
APEX1 P27695 1/20 0.40
MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29903935 0.94 GPR3 (0.54) HPRT1GPR3ALDH1A1HSD17B10CYP2A6
SCHEMBL1294668 0.94 GPR3 (0.54) HPRT1GPR3ALDH1A1HSD17B10CYP2A6
SCHEMBL21789326 0.87 HPRT1 (0.70) HPRT1ALDH1A1HSD17B10CYP2A6TSHR
SCHEMBL15497424 0.87 GPR3 (0.68) GPR3ALDH1A1MAPTRAB9AHPGD
SCHEMBL45841 0.84 GPR3 (0.48) HPRT1GPR3ALDH1A1HSD17B10CYP2A6
SCHEMBL12269172 0.83 GPR3 (0.52) GPR3ALDH1A1HSD17B10MAPTCYP1B1
SCHEMBL12069799 0.83 HPRT1 (0.64) HPRT1ALDH1A1HSD17B10CYP2A6TSHR
SCHEMBL2606564 0.82 GPR3 (0.46) HPRT1GPR3ALDH1A1HSD17B10CYP2A6
Phenanthrene SCHEMBL16752562 0.82 GPR3 (0.70) HPRT1GPR3ALDH1A1HSD17B10CYP2A6
SCHEMBL13562200 0.82 CYP2A6 (0.42) HPRT1GPR3ALDH1A1HSD17B10CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120156798-A1 DETERMINATION OF CORES OR BUILDING BLOCKS AND RECONSTRUCTION OF PARENT MOLECULES IN HEAVY PETROLEUMS AND OTHER HYDROCARBON RESOURCES EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2012-06-21 US disclosed