Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10173892 | 0.93 | GAA (0.54) | GAAPKMSMN1; SMN2KMT2AACHE | |
| SCHEMBL9965459 | 0.92 | GAA (0.53) | GAAPKMSMN1; SMN2KMT2AACHE | |
| SCHEMBL14639717 | 0.87 | GAA (0.49) | GAAPKMSMN1; SMN2KMT2AACHE | |
| SCHEMBL14639656 | 0.84 | PTPN1 (0.49) | GAAPKMKMT2AACHEBACE1 | |
| SCHEMBL642196 | 0.83 | GAA (0.56) | GAAPKMSMN1; SMN2KMT2AACHE | |
| SCHEMBL9965441 | 0.82 | SMN1; SMN2 (0.48) | GAAPKMSMN1; SMN2KMT2AACHE | |
| SCHEMBL9965398 | 0.81 | SMN1; SMN2 (0.50) | GAAPKMSMN1; SMN2KMT2AACHE | |
| SCHEMBL9965426 | 0.81 | GAA (0.56) | GAAPKMKMT2AACHEBACE1 | |
| SCHEMBL9965428 | 0.81 | GAA (0.53) | GAAPKMSMN1; SMN2KMT2AACHE | |
| SCHEMBL641308 | 0.80 | STS (0.55) | GAAPKMKMT2AACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960347-B1 | 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 (17BETA-HSD3) INHIBITORS | STERIX LTD (GB) | 2012-06-20 | — | — | EP | disclosed |