Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL996646 | 1.00 | TNFRSF1A (0.48) | TNFRSF1AALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL996979 | 0.88 | TUBB4A (0.52) | TNFRSF1AALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL996977 | 0.88 | TUBB4A (0.52) | TNFRSF1AALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL997146 | 0.86 | TUBB1 (0.48) | ALDH1A1LMNAMAPTKDM4EAPP | |
| SCHEMBL997147 | 0.86 | TUBB1 (0.48) | ALDH1A1LMNAMAPTKDM4EAPP | |
| SCHEMBL997271 | 0.85 | TUBB1 (0.48) | TNFRSF1AALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL997270 | 0.85 | TUBB1 (0.48) | TNFRSF1AALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL18987303 | 0.83 | MAPT (0.51) | ALDH1A1LMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL996681 | 0.79 | TUBB4A (0.62) | TNFRSF1ALMNAMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL996680 | 0.79 | TUBB4A (0.62) | TNFRSF1ALMNAMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |