Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 9/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.47 |
| ▸ | CDK2 | P24941 | 9/20 | 0.47 |
| ▸ | CDK9 | P50750 | 9/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9967203 | 0.79 | GSK3A (0.43) | CCNT1CCNA2CDK2CDK9KIT | |
| SCHEMBL1836259 | 0.77 | CCNT1 (0.76) | CCNT1CCNA2CDK2CDK9PDPK1 | |
| SCHEMBL20846122 | 0.74 | KIT (0.51) | CDK2CDK1KITCLK1CLK2 | |
| SCHEMBL23655695 | 0.73 | CDK2 (0.45) | CCNT1CCNA2CDK2CDK9CLK1 | |
| SCHEMBL26174709 | 0.73 | PRKCI (0.54) | CCNT1CCNA2CDK2CDK9LRRK2 | |
| SCHEMBL24059791 | 0.72 | GSK3A (0.48) | CDK2CLK1CLK2DYRK1ADYRK2 | |
| SCHEMBL15345020 | 0.72 | CCR1 (0.43) | CCR1CCR5CCR8CCNB2CDK1 | |
| SCHEMBL14041214 | 0.72 | MET (0.43) | KIT | |
| SCHEMBL15345166 | 0.71 | MET (0.48) | CCNT1CCNA2CDK2CDK9CCR1 | |
| SCHEMBL20561743 | 0.71 | KIT (0.39) | CDK2KITCLK1CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083122-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |