Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9931009 | 0.84 | CCR2 (0.62) | CCR2PKMHTT | |
| SCHEMBL9930986 | 0.83 | CCR2 (0.67) | CCR2PKMMEN1KMT2A | |
| SCHEMBL9931481 | 0.81 | CCR2 (0.77) | CCR2PKMHTTMEN1KMT2A | |
| SCHEMBL9931048 | 0.79 | CCR2 (0.77) | CCR2PKMHTTMEN1KMT2A | |
| SCHEMBL9930558 | 0.79 | CCR2 (0.77) | CCR2PKMHTTMEN1KMT2A | |
| SCHEMBL9930852 | 0.79 | CCR2 (0.81) | CCR2PKMMEN1KMT2ABRAF | |
| SCHEMBL9930768 | 0.78 | CCR2 (0.62) | CCR2PKMHTTBRAF | |
| SCHEMBL9930692 | 0.77 | CCR2 (0.78) | CCR2PKMHTTMEN1KMT2A | |
| SCHEMBL9930526 | 0.77 | CCR2 (0.81) | CCR2PKMBRAF | |
| SCHEMBL9930745 | 0.77 | CCR2 (0.81) | CCR2PKMHTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2955173-B1 | 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2017-10-04 | — | — | EP | disclosed |
| EP-2955173-A1 | NOVEL 1,2-BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2015-12-16 | — | — | EP | disclosed |
| EP-2651901-B1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2012082633-A1 | NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-21 | — | — | WO | disclosed |