Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9932266 | 0.90 | MEN1 (0.58) | MEN1KMT2AGRM2KDM4ENPC1 | |
| SCHEMBL9932291 | 0.89 | MEN1 (0.48) | MEN1KMT2AGRM2SMOHDAC1 | |
| SCHEMBL9932455 | 0.85 | ITGB2 (0.49) | MEN1KMT2ASMOKDM4EALDH1A1 | |
| SCHEMBL9932994 | 0.84 | MEN1 (0.46) | MEN1KMT2AGRM2SMOKDM4E | |
| SCHEMBL9932684 | 0.84 | ALDH1A1 (0.46) | MEN1KMT2AGRM2SMOKDM4E | |
| SCHEMBL9968330 | 0.84 | MEN1 (0.55) | MEN1KMT2AGRM2KDM4ENPC1 | |
| SCHEMBL9968309 | 0.84 | MEN1 (0.55) | MEN1KMT2AGRM2KDM4ENPC1 | |
| SCHEMBL9931742 | 0.82 | MEN1 (0.50) | MEN1KMT2AGRM2SMOKDM4E | |
| SCHEMBL9968482 | 0.82 | MEN1 (0.52) | MEN1KMT2AGRM2KDM4ENPC1 | |
| SCHEMBL9932662 | 0.81 | ITGB2 (0.44) | MEN1KMT2AGRM2SMOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | MEN1 1168/4885KMT2A 310/4885GRM2 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.