Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9932768 | 0.94 | KMT2A (0.47) | KDM4EHSD17B10HSD11B1KMT2ASMO | |
| SCHEMBL9932792 | 0.92 | SMO (0.51) | KDM4EHSD17B10GLAHSD11B1KMT2A | |
| SCHEMBL1533860 | 0.90 | SMO (0.50) | KDM4EHSD17B10HSD11B1KMT2ASMO | |
| SCHEMBL1533871 | 0.88 | SMO (0.47) | HSD11B1SMOSMN1; SMN2GAATSHR | |
| SCHEMBL9931499 | 0.86 | SMO (0.53) | KDM4EHSD11B1KMT2ASMOSMN1; SMN2 | |
| SCHEMBL1533937 | 0.84 | HSD11B1 (0.43) | KDM4EHSD11B1KMT2ASMOSMN1; SMN2 | |
| SCHEMBL9932106 | 0.83 | SMO (0.48) | KDM4EHSD11B1KMT2ASMOSMN1; SMN2 | |
| SCHEMBL9932811 | 0.81 | CKS1B (0.47) | KDM4EKMT2ASMOGAAMAPT | |
| SCHEMBL9932536 | 0.80 | SMO (0.62) | HSD17B10KMT2ASMOGAALMNA | |
| SCHEMBL9931814 | 0.80 | SMO (0.49) | KDM4EHSD11B1SMOGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | KDM4E 258/4885HSD17B10 3995/4885GLA 2887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.