Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 14/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968953 | 0.92 | S1PR1 (0.59) | S1PR1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL2806764 | 0.86 | S1PR1 (0.64) | S1PR1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL2774025 | 0.83 | S1PR1 (0.74) | S1PR1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL410946 | 0.79 | L3MBTL1 (0.48) | HSD17B10MAPTTSHRRAB9AMAPK1 | |
| SCHEMBL2775237 | 0.78 | S1PR1 (0.88) | S1PR1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL13416232 | 0.78 | S1PR1 (0.82) | S1PR1SMN1; SMN2HSD17B10KDM4ENPC1 | |
| SCHEMBL2804391 | 0.78 | S1PR1 (0.66) | S1PR1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL2771854 | 0.77 | S1PR1 (0.64) | S1PR1SMN1; SMN2HSD17B10KDM4EHPGD | |
| SCHEMBL2775433 | 0.77 | S1PR1 (0.64) | S1PR1SMN1; SMN2HSD17B10NPSR1MAPT | |
| SCHEMBL2771919 | 0.77 | S1PR1 (0.67) | S1PR1SMN1; SMN2HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202865-B2 | Oxadiazole derivatives | MERCK SERONO SA (CH) | 2012-06-19 | — | — | US | disclosed |
| US-8202865-B2 | Oxadiazole derivatives | MERCK SERONO SA (CH) | 2012-06-19 | — | — | US | disclosed |
| US-20100240658-A1 | Oxadiazole Derivatives | MERCK SERONO SA (CH) | 2010-09-23 | — | — | US | disclosed |
| US-20100240658-A1 | Oxadiazole Derivatives | MERCK SERONO SA (CH) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240658-A1 | Oxadiazole Derivatives | OXA1L, RO60, NQO2 | S1PR1 483/4885SMN1; SMN2 1346/4885HSD17B10 3180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.