Sugi Predict

Sugi Predict / Compounds / SCHEMBL996947

SCHEMBL996947

SCHEMBL996947

CCN(CC)c1ccc2nc3c4ccc(Br)cc4/c(=N/c4ccccn4)cc-3oc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.56
▸ KMT2A Q03164 3/20 0.56
▸ NPC1 O15118 2/20 0.56
▸ RAB9A P51151 2/20 0.56
▸ POLB P06746 1/20 0.56
▸ SCP2 P22307 1/20 0.43
▸ RXFP1 Q9HBX9 1/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ HIF1A Q16665 2/20 0.35
▸ STAT3 P40763 1/20 0.35
▸ STAT1 P42224 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ GPR84 Q9NQS5 10/20 0.34
▸ HTT P42858 2/20 0.34
▸ GLA P06280 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ CASP1 P29466 2/20 0.33
▸ CASP7 P55210 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL996949 1.00 MEN1 (0.56) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL12925167 1.00 MEN1 (0.56) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL12925199 0.92 KMT2A (0.63) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL996049 0.92 KMT2A (0.63) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL996050 0.92 KMT2A (0.63) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL13470150 0.91 NPC1 (0.56) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL995724 0.84 MEN1 (0.53) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL12925210 0.84 MEN1 (0.53) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL1012424 0.84 MEN1 (0.53) MEN1KMT2ANPC1RAB9APOLB
SCHEMBL998274 0.82 MEN1 (0.66) MEN1KMT2ANPC1RAB9APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2269996-B1 MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXANTHIN COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTING OR TREATING PROTOZOAL DISEASE HOSHI UNIVERSITY (JP) 2012-10-17 — — EP disclosed
US-8288374-B2 Medicinal composition containing benzo[a]phenoxazine compound as the active ingredient for prevention or treatment of protozoal disease HOSHI UNIVERSITY (JP) 2012-10-16 — — US disclosed
US-20110021450-A1 MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXAZINE COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTOZOAL DISEASE HOSHI UNIVERSITY (JP) 2011-01-27 — — US disclosed
EP-2269996-A1 MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXANTHIN COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTING OR TREATING PROTOZOAL DISEASE Hoshi University (JP) 2011-01-05 — — EP disclosed
WO-2009113569-A1 MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXANTHIN COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTING OR TREATING PROTOZOAL DISEASE 学校法人星薬科大学 (JP) 2009-09-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021450-A1 MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXAZINE COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTOZOAL DISEASE TBCA, THPO, PAOX MEN1 3404/4885KMT2A 1438/4885NPC1 2025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.