Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 8/20 | 0.76 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.51 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.47 |
| ▸ | AHCY | P23526 | 1/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.46 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.44 |
| ▸ | DPY30 | Q9C005 | 1/20 | 0.44 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.44 |
| ▸ | GNMT | Q14749 | 1/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970625 | 0.95 | DOT1L (0.73) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970636 | 0.91 | DOT1L (0.63) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9936960 | 0.90 | DOT1L (0.63) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9940849 | 0.88 | DOT1L (0.59) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970202 | 0.88 | DOT1L (0.61) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15829716 | 0.88 | DOT1L (0.61) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15829364 | 0.88 | DOT1L (0.61) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970708 | 0.87 | DOT1L (0.61) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15395645 | 0.87 | DOT1L (0.59) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15598668 | 0.87 | DOT1L (0.58) | DOT1LPI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |