Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 8/20 | 0.63 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.53 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.53 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.53 |
| ▸ | AMD1 | P17707 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | AHCY | P23526 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970202 | 0.95 | DOT1L (0.61) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15829716 | 0.95 | DOT1L (0.61) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970243 | 0.91 | DOT1L (0.76) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL16705108 | 0.90 | PI4KA (0.55) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970708 | 0.89 | DOT1L (0.61) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15395645 | 0.89 | DOT1L (0.59) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL15598668 | 0.89 | DOT1L (0.58) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970170 | 0.89 | DOT1L (0.58) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970625 | 0.88 | DOT1L (0.73) | DOT1LPI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9970336 | 0.88 | DOT1L (0.59) | DOT1LPI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |