Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL997071 | 1.00 | MAPT (0.59) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL1000006 | 0.92 | MAPT (0.59) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL1000008 | 0.92 | MAPT (0.59) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL996877 | 0.87 | ABCG2 (0.56) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL996875 | 0.87 | ABCG2 (0.56) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL997652 | 0.84 | MAPT (0.54) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL997653 | 0.84 | MAPT (0.54) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL996700 | 0.84 | ABCG2 (0.56) | MAPTMEN1KMT2ASMN1; SMN2TNFRSF1A | |
| SCHEMBL996701 | 0.84 | ABCG2 (0.56) | MAPTMEN1KMT2ASMN1; SMN2TNFRSF1A | |
| SCHEMBL999702 | 0.81 | MAPT (0.49) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |