Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.66 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.66 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.66 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.53 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.53 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.53 |
| ▸ | AMD1 | P17707 | 4/20 | 0.53 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.50 |
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AHCY | P23526 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.44 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15390046 | 0.93 | PI4KA (0.68) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL17153318 | 0.89 | PI4KA (0.70) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970159 | 0.89 | PI4KA (0.70) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970632 | 0.88 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395524 | 0.88 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL954215 | 0.88 | PI4KA (0.75) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970711 | 0.88 | PI4KA (0.75) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL12915019 | 0.88 | PI4KA (0.75) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395676 | 0.87 | PI4KA (0.68) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL954367 | 0.87 | PI4KA (0.68) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |