Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.68 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.68 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.55 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.55 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.55 |
| ▸ | AMD1 | P17707 | 5/20 | 0.54 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 8/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.50 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10663829 | 0.99 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970637 | 0.97 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395675 | 0.97 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL17153318 | 0.94 | PI4KA (0.70) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970159 | 0.94 | PI4KA (0.70) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395676 | 0.93 | PI4KA (0.68) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395668 | 0.92 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL15395646 | 0.92 | PI4KA (0.72) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL9970659 | 0.90 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBRXFP1 | |
| SCHEMBL954215 | 0.90 | PI4KA (0.75) | PI4KAPI4K2BPI4K2API4KBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | claimed |
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. | 2016-03-10 | — | — | US | disclosed |
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. | 2016-03-10 | — | — | US | disclosed |
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. | 2016-03-10 | — | — | US | disclosed |
| US-9029343-B2 | Modulators of histone methyltransferase, and methods of use thereof | Epizyme, Inc. (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029343-B2 | Modulators of histone methyltransferase, and methods of use thereof | Epizyme, Inc. (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029343-B2 | Modulators of histone methyltransferase, and methods of use thereof | Epizyme, Inc. (US) | 2015-05-12 | — | — | US | disclosed |
| US-8637485-B2 | 5′,-substituted adenosynes preparation thereof and use as inhibitors of S-adenosylmethionine decarboxylase | SOUTHERN RESEARCH INSTITUTE (US) | 2014-01-28 | — | — | US | disclosed |
| US-20130310333-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. (US) | 2013-11-21 | — | — | US | disclosed |
| US-20130310333-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. (US) | 2013-11-21 | — | — | US | disclosed |
| EP-2574616-A2 | 5'-substituted adenosynes, preparation thereof and use as inhibitors of s-adenosylmethionine decarboxylase. | Southern Research Institute (US) | 2013-04-03 | — | — | EP | disclosed |
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | disclosed |
| US-4794174-A | ENZYME INHIBITORS | SOUTHERN RESEARCH INSTITUTE (US) | 1988-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160068559-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | EHMT1, EHMT2, HNMT | PI4KA 1844/4885PI4K2B 1901/4885PI4K2A 1942/4885 |
| US-20130310333-A1 | Modulators of Histone Methyltransferase, and Methods of Use Thereof | EHMT1, EHMT2, HNMT | PI4KA 1844/4885PI4K2B 1901/4885PI4K2A 1942/4885 |
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | AMD1, ADA, MTAP | PI4KA 2084/4885PI4K2B 2914/4885PI4K2A 3027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.