Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.51 |
| ▸ | TUBB | P07437 | 3/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL997072 | 1.00 | MAPT (0.55) | MAPTALDH1A1LMNANPSR1TUBB4A | |
| SCHEMBL996839 | 0.97 | MAPT (0.55) | MAPTALDH1A1LMNANPSR1TUBB4A | |
| SCHEMBL996841 | 0.97 | MAPT (0.55) | MAPTALDH1A1LMNANPSR1TUBB4A | |
| SCHEMBL996692 | 0.89 | TUBB4A (0.61) | MAPTALDH1A1LMNANPSR1TUBB4A | |
| SCHEMBL996693 | 0.89 | TUBB4A (0.61) | MAPTALDH1A1LMNANPSR1TUBB4A | |
| SCHEMBL994242 | 0.88 | TUBB1 (0.55) | MAPTALDH1A1LMNANPSR1TUBB4A | |
| SCHEMBL994243 | 0.88 | TUBB1 (0.55) | MAPTALDH1A1LMNANPSR1TUBB4A | |
| SCHEMBL997966 | 0.87 | TUBB1 (0.54) | LMNATUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL997100 | 0.87 | TUBB1 (0.54) | MAPTALDH1A1TUBB4ATUBBTUBA3C | |
| SCHEMBL997967 | 0.87 | TUBB1 (0.54) | LMNATUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | claimed |
| WO-2011009826-A2 | NOVEL CHALCONE DERIVATIVES WITH CYTOTOXIC ACTIVITY | ADAMED Sp.z o.o. (PL) | 2011-01-27 | — | — | WO | disclosed |