Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.30 |
| ▸ | SRC | P12931 | 2/20 | 0.30 |
| ▸ | PRKACA | P17612 | 2/20 | 0.30 |
| ▸ | FLT3 | P36888 | 2/20 | 0.30 |
| ▸ | GSK3A | P49840 | 2/20 | 0.30 |
| ▸ | GSK3B | P49841 | 2/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977698 | 0.77 | PIK3CG (0.35) | PIK3CGPIK3CAPIK3CDSRCPRKACA | |
| SCHEMBL9977736 | 0.75 | GSK3A (0.35) | PIK3CGPIK3CAPIK3CDSRCPRKACA | |
| SCHEMBL15401556 | 0.73 | GSK3A (0.51) | GSK3AGSK3B | |
| SCHEMBL175432 | 0.72 | RET (0.38) | GSK3AGSK3BJAK2 | |
| SCHEMBL30440210 | 0.72 | RET (0.38) | GSK3AGSK3BJAK2 | |
| SCHEMBL19249457 | 0.72 | CSNK1D (0.37) | PRKACAFLT3GSK3AGSK3BJAK2 | |
| SCHEMBL17403252 | 0.71 | GSK3A (0.33) | PIK3CGPIK3CAPIK3CDSRCPRKACA | |
| SCHEMBL15400920 | 0.71 | GSK3A (0.43) | SRCFLT3GSK3AGSK3BJAK2 | |
| SCHEMBL15400921 | 0.71 | GSK3A (0.43) | SRCFLT3GSK3AGSK3BJAK2 | |
| SCHEMBL21345178 | 0.70 | PIK3CG (0.33) | PIK3CGPIK3CAPIK3CDSRCPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083121-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |