Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 10/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.35 |
| ▸ | GSK3A | P49840 | 12/20 | 0.34 |
| ▸ | GSK3B | P49841 | 12/20 | 0.34 |
| ▸ | FLT3 | P36888 | 10/20 | 0.34 |
| ▸ | JAK2 | O60674 | 7/20 | 0.34 |
| ▸ | SRC | P12931 | 6/20 | 0.34 |
| ▸ | PLK1 | P53350 | 6/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.34 |
| ▸ | PRKACA | P17612 | 5/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977736 | 0.86 | GSK3A (0.35) | PIK3CGPIK3CAGSK3AGSK3BFLT3 | |
| SCHEMBL19250682 | 0.86 | SGK1 (0.33) | — | |
| SCHEMBL19250804 | 0.86 | NOS3 (0.33) | PIK3CA | |
| SCHEMBL17403252 | 0.83 | GSK3A (0.33) | PIK3CGPIK3CAGSK3AGSK3BFLT3 | |
| SCHEMBL19250832 | 0.82 | SGK1 (0.30) | — | |
| SCHEMBL19250685 | 0.82 | SGK1 (0.30) | — | |
| SCHEMBL19255693 | 0.81 | EGFR (0.31) | — | |
| SCHEMBL19244048 | 0.80 | — | — | |
| SCHEMBL9977719 | 0.80 | ATR (0.34) | PIK3CGPIK3CAPIK3CDPIK3CBCDK2 | |
| SCHEMBL22894098 | 0.79 | GSK3A (0.39) | PIK3CGPIK3CAGSK3AGSK3BFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3502112-A1 | ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVE | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2019-06-26 | — | — | EP | disclosed |
| WO-2017134226-A1 | ASSAY FOR COMPOUNDS HAVING ACTIVITY AGAINST INFLUENZA | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-10 | — | — | WO | disclosed |
| WO-2017133667-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |
| WO-2012083117-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-21 | — | — | WO | disclosed |