Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.62 |
| ▸ | MAOB | P27338 | 4/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.62 |
| ▸ | SDHA | P31040 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CALML3 | P27482 | 1/20 | 0.62 |
| ▸ | F10 | P00742 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12967058 | 1.00 | MAOA (0.62) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL14270037 | 1.00 | MAOA (0.62) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL19941272 | 0.89 | MAOA (0.63) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL4899261 | 0.84 | MAOA (0.65) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL16093305 | 0.82 | MAOA (0.56) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL14270221 | 0.82 | MAOA (0.56) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL19937993 | 0.82 | MAOA (0.64) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL9969390 | 0.82 | MAOA (0.64) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL3181066 | 0.80 | MAOA (0.60) | MAOAMAOBPTGS1SDHALMNA | |
| SCHEMBL7815405 | 0.79 | MAOA (0.72) | MAOAMAOBPTGS1SDHALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841263-B2 | Macrocyclic compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2014-09-23 | — | — | US | disclosed |
| US-8202843-B2 | Macrocyclic compounds and methods of making and using the same | RIB-X PHARMACEUTICALS, INC. (US) | 2012-06-19 | — | — | US | disclosed |