Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | GUSB | P08236 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA6 | P23280 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839194 | 0.79 | KDM4E (0.57) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL9315349 | 0.77 | MAPT (0.55) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL7830798 | 0.77 | KDM4E (0.55) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL6769385 | 0.76 | MAPT (0.63) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL21843777 | 0.76 | GPR52 (0.49) | HPGDSMN1; SMN2BCHEALDH1A1 | |
| SCHEMBL18379309 | 0.76 | MAPT (0.63) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL15938647 | 0.74 | MAPT (0.61) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL8644817 | 0.74 | MAPT (0.67) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL28714567 | 0.74 | MAPT (0.61) | KDM4EMAPTHPGDSMN1; SMN2BCHE | |
| SCHEMBL28702840 | 0.74 | MAPT (0.61) | KDM4EMAPTHPGDSMN1; SMN2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202861-B2 | Drugs for various disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-19 | — | — | US | disclosed |