Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9974189 | 0.92 | GPR119 (0.48) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL9974231 | 0.89 | GPR119 (0.48) | GPR119 | |
| SCHEMBL9974229 | 0.88 | GPR119 (0.49) | GPR119PTPN2PTPN1PTPN6ALOX5AP | |
| SCHEMBL9974192 | 0.87 | GPR119 (0.49) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL9943189 | 0.87 | GPR119 (0.60) | GPR119 | |
| SCHEMBL14244245 | 0.86 | GPR119 (0.55) | GPR119 | |
| SCHEMBL9974230 | 0.86 | GPR119 (0.52) | GPR119 | |
| SCHEMBL9943220 | 0.86 | GPR119 (0.50) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL9943216 | 0.86 | GPR119 (0.47) | GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL14244615 | 0.85 | GPR119 (0.49) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012080476-A1 | FUSED DIHYDROPYRANS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY AND RELATED DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | WO | disclosed |