⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5142057 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL6235646 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL16892582 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL7453221 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL198272 | 1.00 | — | — | |
| SCHEMBL1770447 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL5073915 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL5249016 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL5246477 | 1.00 | EPHX1 (0.55) | — | |
| SCHEMBL434754 | 0.97 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1813636-A1 | Polyamine analogs that activate antizyme frameshifting | MediQuest Therapeutics, Inc. (US) | 2007-08-01 | — | — | EP | claimed |
| EP-1730100-A1 | POLYAMINE ANALOGS THAT ACTIVATE ANTIZYME FRAMESHIFTING | MediQuest Therapeutics, Inc. (US) | 2006-12-13 | — | — | EP | claimed |
| WO-2005105729-A1 | POLYAMINE ANALOGS THAT ACTIVATE ANTIZYME FRAMESHIFTING | MEDIQUEST THERAPEUTICS, INC. (US) | 2005-11-10 | — | — | WO | claimed |
| US-20040209926-A1 | Polyamine analogs that activate antizyme frameshifting | MEDIQUEST THERAPEUTICS, INC. | 2004-10-21 | — | — | US | claimed |
| US-20040058954-A1 | Polyamine analogs that activate antizyme framshifting | MEDIQUEST THERAPEUTICS, INC. | 2004-03-25 | — | — | US | claimed |
| EP-3831372-A1 | MITOGUAZONE FOR PREVENTING THE RELAPSE OR THE PROGRESSION OF MULTIPLE SCLEROSIS | Pathologica LLC (US) | 2021-06-09 | — | — | EP | disclosed |
| US-10350178-B2 | Methods and compositions for treatment of demyelinating diseases | PATHOLOGICA LLC (US) | 2019-07-16 | — | — | US | disclosed |
| EP-3473247-A1 | COMPOSITION FOR ORAL DELIVERY COMPRISING MGBG FOR USE IN TREATING MULTIPLE SCLEROSIS | Pathologica LLC (US) | 2019-04-24 | — | — | EP | disclosed |
| US-20180360783-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF DEMYELINATING DISEASES | PATHOLOGICA LLC | 2018-12-20 | — | — | US | disclosed |
| EP-2453886-B1 | PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE | PATHOLOGICA LLC (US) | 2018-12-12 | — | — | EP | disclosed |
| EP-2894685-B1 | BENZOTHIENOBENZOTHIOPHENE DERIVATIVE, ORGANIC SEMICONDUCTOR MATERIAL, AND ORGANIC TRANSISTOR | DAINIPPON INK & CHEMICALS (JP) | 2018-10-31 | — | — | EP | disclosed |
| US-10085955-B2 | Methods and compositions for treatment of demyelinating diseases | PATHOLOGICA LLC (US) | 2018-10-02 | — | — | US | disclosed |
| WO-2011009039-A2 | PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE | PATHOLOGICA LLC (US) | 2011-01-20 | — | — | WO | disclosed |
| EP-1813636-A1 | Polyamine analogs that activate antizyme frameshifting | MediQuest Therapeutics, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| US-7144920-B2 | Polyamine analogs that activate antizyme frameshifting | MEDIQUEST THERAPEUTICS, INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-6914079-B2 | Polyamine analogs that activate antizyme frameshifting | MEDIQUEST THERAPEUTICS, INC. (US) | 2005-07-05 | — | — | US | disclosed |
| US-20040209926-A1 | Polyamine analogs that activate antizyme frameshifting | MEDIQUEST THERAPEUTICS, INC. | 2004-10-21 | — | — | US | disclosed |
| US-6723745-B2 | PREVENTION OR TREATMENT OF AUTOIMMUNE DISEASE IN WARM BLOODED ANIMAL | SANKYO COMPANY, LIMITED (JP) | 2004-04-20 | — | — | US | disclosed |
| US-20040058954-A1 | Polyamine analogs that activate antizyme framshifting | MEDIQUEST THERAPEUTICS, INC. | 2004-03-25 | — | — | US | disclosed |
| EP-1167375-A1 | ERYTHROMYCIN DERIVATIVES | HOKURIKU SEIYAKU CO., LTD. (JP) | 2002-01-02 | — | — | EP | disclosed |